DESCRIPTION

The HemoCue Glucose 201 Analyzer is a handheld instrument and reports plasma equivalent values. The HemoCue Glucose 201 Analyzer is available with data management capabilities.        Saponin hemolyzes the erythrocytes and their contents are released. alfa-D-glucose is transformed to beta-D-glucose using the mutarotase enzyme. The GDH enzyme (glucose dehydrogenase), specific for beta-D-glucose, acts as a catalyst in the oxidation of beta-D-glucose in the presence of NAD (nicotinamide adenine dinucleotide) to form NADH.        The GDH/mutarotase enzyme system ensures a molar relationship between the available glucose and the NADH produced. In the presence of NADH, using diaphorase as a catalyst, the MTT chromogene (a tetrazolium salt) is formed to a colored formazan. The colored formazan is quantified photometrically with a two-wavelength method (660 nm and 840 nm).        The HemoCue Glucose Systems are based on a glucose dehydrogenase method and consists of a small, dedicated analyzer and a unique disposable microcuvette.        The systems combine the precision and accuracy of a central laboratory with the speed and convenience of obtaining results at the point-of-care. Following the three simple steps, the HemoCue Glucose Systems will produce lab-accurate results for diagnosing or monitoring diabetes, as well as monitoring neonatal blood glucose levels.