Molecular Devices - ImageXpress Confocal
by Molecular Devices

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DESCRIPTION

Histology Analyzer

The ImageXpress® Confocal HT.ai High-Content Imaging System utilizes a seven-channel laser light source with eight imaging channels to enable highly multiplexed assays while maintaining high throughput by using shortened exposure times. Water immersion objectives improve image resolution and minimize aberrations so scientists can see deeper into thick samples. 


The powerful combination of MetaXpress® software and IN Carta® software simplifies workflows for advanced phenotypic classification and 3D image analysis with machine learning capabilities and an intuitive user interface.

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FEATURES

High-intensity laser light source

  • Capture images faster with shorter exposure times. Multiplex your experiments with 7 lasers and 8 imaging channels.


Accurate 3D measurements

  • Custom Module Editor 3D analysis is optimized for confocal imaging, enabling 3D measurements of volume and distance.


Wide field of view

  • Wide field of view enables whole-well confocal imaging and eliminates missed targets. Next-generation dual microlens enhanced spinning disk technology provides a large, flat field of view for more accurate and reproducible analysis.


Exclusive AgileOptix™ spinning disk technology

  • Provides increased sensitivity with specially designed optics, high-powered laser illumination, and sCMOS sensor. Swappable disk geometries provide flexibility between speed and resolution.


IN Carta Image Analysis Software

  • Leverages machine learning to improve the accuracy and robustness of high-content image analysis, delivering data insights that other technologies miss. Reduces the complexity of image analysis with intuitive guided workflows in a modern user interface.


Multiple imaging modes

  • The system offers phase contrast and brightfield label-free imaging, widefield and confocal fluorescent imaging with water immersion optics as a standard option.


Automated water immersion objective technology

  • Offers greater image resolution and sensitivity with up to 4x increase in signal leading to lower exposure times.


Wide dynamic range

  • Quantifies low and high intensity signals in a single image with >3 log dynamic range intensity detection.

Additional Specifications

Camera

  • >4 megaPixel sCMOS


Field of view 10x

  • 1.96 mm2

Speed

  • >200,000 wells/day


Objectives

  • Air (2x-100x), Oil (40x, 60x, 100x), and Water (20x, 40x, 60x)


Filter changer

  • 8 position emission wheel and 5 position dichroic filter wheel


Autofocus

  • Laser+image autofocus

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